Direct and Indirect Free Thyroxine Assay Methods: Theory and Practice
نویسندگان
چکیده
منابع مشابه
Direct and indirect free thyroxine assay methods: theory and practice.
BACKGROUND For the diagnosis of thyroid disease, measurement of "free hormone" is generally accepted as an appropriate measure. However, valid assays measuring the free fraction of thyroxine (FT4) ideally must perform without bias, despite large variations in the concentrations and affinities of serum T4-binding proteins in the population. Several approaches have been taken to overcome such bia...
متن کاملClinical problems with a free thyroxine assay.
THE measurement of serum free thyroxine (FT4), which forms a small fraction (0.01-0.05 per cent) of the circulating total thyroxine (TT4), might be expected to provide the most accurate single biochemical index of thyroid status, on the basis that only free hormone is bioavailable. The conventional estimation of FT4 by equilibrium dialysis' is time consuming and the arrival of radioimmunoassay ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2001
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/47.8.1353